Common Antibiotics Used for a Tooth Infection

Penicillin-type drugs, such as amoxicillin and penicillin V potassium, are typically the first-line antibiotics that dentists prescribe to treat a tooth infection.

However, allergic reactions to penicillins are common. If you have a history of allergy symptoms (such as hives, swelling, or low blood pressure) after taking penicillin-type drugs, let your dentist know. They may prescribe a macrolide antibiotic, such as clindamycin, to clear up your infection. 

In some cases, your dentist may prescribe another type of antibiotic, such as:

  • Augmentin (amoxicillin with clavulanate)
  • Flagyl (metronidazole)

These drugs are typically prescribed if other antibiotics don’t work to treat your symptoms or if your tooth infection begins to spread.


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